Weird problem with NRIRServer for NetRemote and USB-UIRT

I use my USB-UIRT both with NRIRServ and Girder (for automation), and since I made my new HTPC I have had a strange problem: With NRIRServ I can send a few codes, and then it's dead until I reboot the HTPC. And Girder can't use the USB-UIRT either. Using Girder (without touching NRIRserver) I can send as many codes as fast as I want to. I have the same driver, the same Girder plug-in and the same NRIRserver plug-in. Hold-button repeats are disabled, and the delay is set to 1000 ms. Any good ideas here? I'm going insane! When I close NRIRServ after one of these lockups I get "I failed error 10038". Does that tell anybody anything?